Importantly, when the presence/absence of lesions was considered, kappa values did not change significantly for neuropathologists (0.74/95% CI:0.58-0.89 for periventricular and 0.65/95% CI: 0.28-0.99 for deep WM demyelination), improved for radiologists (0.57/95% CI: 0.37-078 for periventricular and 0.50/95% CI: 0.31-0.70 for deep WMHs) but became even worse for radiologic-pathologic correlations (0.05/95% CI:-0.11-0.01 for periventricular and 0.12/95% CI:-0.20-0.43 for deep WM lesions). Another limitation concerns certain a priori choices in respect to the radiological and neuropathological investigations. MRI indicates a few scattered foci of T2/FLAIR hyperintensities in the pons, periventricular and subcortical white matter. White spots on a brain MRI are not always a reason to worry. Histological slides were independently evaluated by two trained neuropathologists without previous knowledge of the MRI data. The present study revealed that brain T2/FLAIR sequence-identified WMHs overestimated demyelination in the periventricular and perivascular regions but underestimated it in the deep WM during normal brain aging. It also acts as a practical framework that allows the radiologists to plan the overall treatment., When examining the MRI scan, doctors and radiologists look for the MRI hyperintensity. WebA hyperintensity or T2 hyperintensity is an area of high intensity on types of magnetic resonance imaging (MRI) scans of the brain of a human or of another mammal that reflect lesions produced largely by demyelination and axonal loss. unable to do more than one thing at a time, like talking while walking. The presence of nonspecific white matter hyperintensities may cause uncertainty for physicians and anxiety for patients. These areas are hyperintense on T2-weighted (T2) and fluid-attenuated inversion recovery (FLAIR) MRI sequences, and by consensus are now referred to as white matter hyperintensities (WMH), or subcortical hyperintensities where deep gray matter is also involved. WMHs are associated with vascular risk factors such as diabetes, smoking and hypertension and hence WMHs are considered part of small vessel disease. WebAnswer (1 of 8): White matter hyperintensities (WMHs) are signal abnormalities in the white matter of the brain found on T2-weighted , fluid-attenuated inversion recovery (FLAIR), and proton density magnetic resonance imaging (MRI) sequences.
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