drug induced exfoliative dermatitis

When less than 10% of the body surface area (BSA) is involved, it is defined SJS, when between 10 and 30% of BSA it is defined overlapping SJS/TEN, when more than 30% of BSA, TEN [2] (Additional file 1: Figure S1, Additional file 2: Figure S2). The epidermal-dermal junction shows changes, ranging from vacuolar alteration to subepidermal blisters [20]. Exfoliative dermatitis is also a risk factor for epidemic spread of methicillin-resistant Staphylococcus aureus.6,20. Genome-scale investigation of drug-induced termination codon-readthrough in a model system of epidermolysis bullosa . Pathophysiology DIP. In: Eisen AZ, Wolff K, editors. Pharmacogenetics studies have found an association between susceptibility to recurrent EM in response to several stimuli and human leukocyte antigen (HLA) haplotypes of class II, in particular HLA DQB1*0301 [23]. Minerva Stomatol. Erythema multiforme. 1991;127(6):83942. Allergy. All Rights Reserved. Granulysin is a key mediator for disseminated keratinocyte death in StevensJohnson syndrome and toxic epidermal necrolysis. Some anti-seizure medicines have also been known to cause exfoliative dermatitis. It was used with success in different case reports [114116]. AR 40-501 Standard of Medical Fitness 14 Jun 2017 Effects of treatments on the mortality of StevensJohnson syndrome and toxic epidermal necrolysis: a retrospective study on patients included in the prospective EuroSCAR Study. Archivio Istituzionale della Ricerca Unimi, Nayak S, Acharjya B. of Internal Medicine, University of Bari, Bari, Italy, Andrea Nico,Elisabetta Di Leo,Paola Fantini&Eustachio Nettis, You can also search for this author in Br J Dermatol. Epidemiological studies on EM, SJS and TEN syndromes report different results, probably related to several biases, such as ethnical differences, diagnostic criteria and drug consumption patterns in different socio-economic systems. PubMed The administration of a single dose of 5mg/kg was able to stop disease progression in 24h and to induce a complete remission in 614days. Supportive and specific care includes both local and systemic measures, as represented in Fig. 2012;167(2):42432. J Invest Dermatol. Patients should be educated to avoid any causative drugs. Mittmann N, et al. Anti-tubercular therapy (ATT) induced exfoliative dermatitis-A case In an open trial on cyclosporine in 29 patients with TEN, the use of Cys A for at least 10days led to a rapid improvement without infective complications [112]. [71] realized an algorhitm named ALDEN (algorithm of drug causality for epidermal necrolysis) which helps to establish a cause/effect relationship as probable or very probable in 70% of cases.

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